Asymmetric synthesis of arylglycine amino acids using (S,S)-(+)-pseudoephedrine derived amides

Authors
Vicario, JL Badia, D Dominguez, E Crespo, A Carrillo, L Anakabe, E
Citation
Jl. Vicario et al., Asymmetric synthesis of arylglycine amino acids using (S,S)-(+)-pseudoephedrine derived amides, TETRAHEDR L, 40(39), 1999, pp. 7123-7126
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
39
Year of publication
1999
Pages
7123 - 7126
Database
ISI
SICI code
0040-4039(19990924)40:39<7123:ASOAAA>2.0.ZU;2-X
Abstract
Arylglycine aminoacids were obtained in good yields and with enantiomeric e xcesses higher than 99% by using an asymmetric amination reaction protocol on (S,S)-(+)-pseudoephedrine based arylacetamide enolates with di-tert-buty lazodicarboxylate. Subsequent hydrazinolysis and hydrolysis yielded the tar get aminoacids. (C) 1999 Published by Elsevier Science Ltd. All rights rese rved.