Transmission of factor VII deficiency through liver transplantation

The Liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmiss ion of protein C deficiency with dysfibrinogenemia and factor XI deficiency In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagula tion disorder, from an affected Liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prol ongation of the prothrombin time and a below-normal level of factor VII, an d has had no bleeding complications.