Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs

Nonsteroidal antiinflammatory drugs (NSAID) are frequently reported to inte rfere with the blood pressure lowering actions of various antihypertensive medications. We studied 17 women with arthritis and hypertension who were r eceiving fosinopril and HCTZ, and administered sequentially in random order ibuprofen, sulindac, and nabumetone for 1 month each, with an intervening 2-week washout period between each treatment period. During the washout per iod, subjects received acetaminophen. Blood pressure at the end of 2 weeks of acetaminophen was compared with blood pressure after 1 month of treatmen t with each of the NSAID. Mean blood pressure was unchanged before and afte r all NSAID: 108 +/- 7 v 107 +/- 9 for nabumetone, 108 +/- 9 v 108 +/- 9 fo r sulindac, and 108 +/- 8 v 107 +/- 9 for ibuprofen. The 24-h urinary sodiu m excretion was not significantly different. We conclude that the three NSA ID did not neutralize the antihypertensive effect of the combination of fos inopril and HCTZ, and hence the blood pressure lowering action of the combi nation may not be prostaglandin dependent. Am J Hypertens 1999;12:925-928 ( C) 1999 American Journal of Hypertension, Ltd.