Ey. Kim et al., Nonspecific interstitial pneumonia with Fibrosis: Serial high-resolution CT findings with functional correlation, AM J ROENTG, 173(4), 1999, pp. 949-953
Citations number
20
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
OBJECTIVE. We assessed serial changes in high-resolution CT findings and pu
lmonary function in patients with nonspecific interstitial pneumonia with f
ibrosis.
MATERIALS AND METHODS. Serial high-resolution CT findings in 13 patients wi
th biopsy-proven nonspecific interstitial pneumonia with fibrosis (mean fol
low-up period, 11 months) and pulmonary function tests (mean follow-up peri
od, 11 months) were retrospectively analyzed. On CT, the presence and exten
t of ground-glass opacity, irregular linear opacity, honeycombing and conso
lidation were assessed.
RESULTS. On initial CT, all patients had areas of ground-glass opacity (mea
n +/- SD, 21.6% +/- 14.4) and irregular linear opacity (5.0% +/- 5.2). The
areas of ground-glass opacity decreased significantly on follow-up CT (13.5
% +/- 10.5, p = .003). The areas of irregular linear opacity decreased slig
htly (4.2% +/- 5.2, p < .05). Initial forced vital capacity (69.4% +/- 16.0
) improved significantly on follow-up examination (83.9% +/- 16.5) (p = .00
3). The decrease in the extent of ground-glass opacity on CT correlated sig
nificantly with changes in forced vital capacity (r = -.702, p = .007) and
diffusing capacity for carbon monoxide (r = -.597, p = .031).
CONCLUSION. In patients with nonspecific interstitial pneumonia with fibros
is, areas of ground-glass opacity decrease on follow-up high-resolution CT,
and the extent of decrease correlates significantly with that of functiona
l improvement.