Chronic inflammatory pseudotumor arising in the hepatobiliary-pancreatic system: Progressive multisystemic organ involvement in four patients

OBJECTIVE. inflammatory pseudotumor is a benign process that can involve mo st organ systems. The purpose of this report was to evaluate the imaging fe atures of multifocal chronic inflammatory pseudotumor in four patients who presented with clinical, radiographic, and biopsy evidence of pancreatic or biliary malignancy. CONCLUSION. To our knowledge, this is the first report in the radiology lit erature describing the imaging features of progressive multifocal inflammat ory pseudotumor originating from a primary pancreatic or biliary focus. Eve n on retrospective review, no distinguishing imaging features were identifi ed that could discriminate benign from malignant disease. These findings em phasize the importance of histopathologic analysis in the diagnosis of mali gnancy, particularly in patients with previously diagnosed inflammatory pse udotumor.