Short report: Effects of pyronaridine on gametocytes in patients with acute uncomplicated falciparum malaria

Authors
Ringwald, P Meche, FS Basco, LK
Citation
P. Ringwald et al., Short report: Effects of pyronaridine on gametocytes in patients with acute uncomplicated falciparum malaria, AM J TROP M, 61(3), 1999, pp. 446-448
Citations number
13
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
ISSN journal
00029637 → ACNP
Volume
61
Issue
3
Year of publication
1999
Pages
446 - 448
Database
ISI
SICI code
0002-9637(199909)61:3<446:SREOPO>2.0.ZU;2-R
Abstract
The effects of pyronaridine and chloroquine on mature Plasmodium falciparum gametocytes were compared in 161 patients treated with chloroquine or pyro naridine. Neither pyronaridine nor chloroquine showed gametocytocidal activ ity. The relative risks of post-treatment gametocytemia after pyronaridine and chloroquine treatment in the presence of chloroquine-resistant isolates were 1.25 and 11.5, respectively, suggesting that the use of chloroquine w as associated with a high risk of favoring post-therapeutic gametocytemia i n chloroquine-resistant infections.