The first legislation in the world, designed to protect animals used in res
earch, was passed in England in 1876, and is still in force today. It is on
e of the strictest in Europe. At the same period, France had no such law, a
nd was the country conducting the greatest amaint of animal experimentation
. Comparing, these two countries, in the middle of the 19th century, can ac
count for this difference. The most important difference seems to be relate
d to the theological question: are animals endowed with a soul? Saint Augus
tine, claimed, in the 4th century, perhaps because of an experiment with th
e centipede, that animals do not have a soul. In the 17th century, Rene Des
cartes, using a different philosophical system, reached a similar conclusio
n, in France. On the other hand, under the influence of Charles Darwin, Eng
land rejected the Roman Catholic conclusion, about the soul of animals. The
industrial revolution, occurring earlier in England than in France, also c
hanged the society, developing urban areas, where people were cut off from
rural life and changing human relationships with animals. The industrial re
volution enabled the development of the press, giving impetus to public opi
nion. These facts, combined with a caution of science, which was more devel
oped in England than in France, brought about the first important "anti-doc
tor" campaign.