The comparison of uterine artery Doppler velocimetry with the histopathology of the placental bed

We determined the relationship between the histopathological findings of th e placental bed and Doppler flow measurements of the uterine artery in wome n with preeclampsia and fetal growth retardation. Doppler velocimetry in th e uterine artery was evaluated in 17 pregnant women with preeclampsia, 15 o f whom had fetal growth retardation, and 20 normal pregnant women, within 1 4 days of Caesarean delivery and placental bed biopsy. The placental bed bi opsies were evaluated in terms of trophoblast migration into the myometrium and physiological changes of the spiral arteries. The results were compare d with Doppler velocimetry values. Trophoblast migration and physiological changes were not detected in 10 (59%) cases with preeclampsia and in 4 (20% ) With normal pregnancies (p<0.05). In the preeclamptic group, 9 of 15 case s that were complicated with intrauterine growth retardation had no trophob lastic migration into the myometrium. The mean systolic/diastolic ratio, re sistance index and pulsatility index of the uterine artery in women with pr ecclampsia and fetal growth retardation was significantly higher than women with normal pregnancies (p<0.01). The mean resistance index of the uterine artery in the impaired migration group was significantly higher than the m igration group (p=0.02). The incidence of impaired trophoblast migration wa s significantly higher in the group with a high systolic/diastolic ratio (a bove 2.5) and resistance index (above 0.58) than cases with low systolic/di astolic ratio and resistance index (72%, 23% respectively, p<0.05). The inc idence of early diastolic notch in the impaired trophoblast migration group was significantly higher than the migration group (57% versus 13%, p<0.01) . Our study supports the hypothesis that high uterine artery now resistance is related to the reduced trophoblast migration into the myometrium and in adequate physiological changes in the spiral arteries in women with intraut erine growth retardation and preeclampsia.