Synthesis and biological evaluation of 2-methoxy- and 2-methylthio-6-[(2 '-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity

Authors
Botta, M Occhionero, F Nicoletti, R Mastromarino, P Conti, C Magrini, M Saladino, R
Citation
M. Botta et al., Synthesis and biological evaluation of 2-methoxy- and 2-methylthio-6-[(2 '-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity, BIO MED CH, 7(9), 1999, pp. 1925-1931
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
7
Issue
9
Year of publication
1999
Pages
1925 - 1931
Database
ISI
SICI code
0968-0896(199909)7:9<1925:SABEO2>2.0.ZU;2-U
Abstract
The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-met hylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished . The activity of these agents against positive strand (rubella virus and s indbis virus) and negative strand (vesicular stomatitis virus) RNA viruses is reported. Some of these compounds are efficient and selective inhibitors of rubella virus. (C) 1999 Elsevier Science Ltd. All rights reserved.