Oligonucleotides containing 4 '-C-aminomethyl-2 '-modified thymidines showincreased binding affinity towards DNA and RNA

Authors
Pfundheller, HM Wengel, J
Citation
Hm. Pfundheller et J. Wengel, Oligonucleotides containing 4 '-C-aminomethyl-2 '-modified thymidines showincreased binding affinity towards DNA and RNA, BIOORG MED, 9(18), 1999, pp. 2667-2672
Citations number
30
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
18
Year of publication
1999
Pages
2667 - 2672
Database
ISI
SICI code
0960-894X(19990920)9:18<2667:OC4''T>2.0.ZU;2-M
Abstract
Oligonucleotides containing 4'-C-aminomethyl-2'-O-methyl or 4'-C-aminomethy l-2'-deoxy-2'-fluoro modified thymidines have been synthesized. Compared wi th the corresponding oligodeoxynucleotide reference these novel oligonucleo tide analogues display increased binding affinity towards complementary sin gle stranded DNA as well as RNA. The possible effect of the positively char ged 4'-C-aminomethyl group has been investigated. (C) 1999 Elsevier Science Ltd. All rights reserved.