3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis

Authors
Pae, AN Kim, SY Kim, HY Joo, HJ Cho, YS Choi, KI Choi, JH Koh, HY
Citation
An. Pae et al., 3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis, BIOORG MED, 9(18), 1999, pp. 2685-2690
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
18
Year of publication
1999
Pages
2685 - 2690
Database
ISI
SICI code
0960-894X(19990920)9:18<2685:3QSONO>2.0.ZU;2-4
Abstract
Three-dimensional QSAR studies for two series of new oxazolidinone antibact erial agents were conducted using the comparative molecular field analysis (CoMFA). In vitro activities (MICs) of the compounds against methicillin-re sistant Staphylococcus aureus 88 (MRSA 88) exhibited a strong correlation w ith their steric, electrostatic factors and lipophilicities. (C) 1999 Elsev ier Science Ltd. All rights reserved.