New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor

Authors
Ruel, R Lacombe, P Abramovitz, M Godbout, C Lamontagne, S Rochette, C Sawyer, N Stocco, R Tremblay, NM Metters, KM Labelle, M
Citation
R. Ruel et al., New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor, BIOORG MED, 9(18), 1999, pp. 2699-2704
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
18
Year of publication
1999
Pages
2699 - 2704
Database
ISI
SICI code
0960-894X(19990920)9:18<2699:NCOBDA>2.0.ZU;2-3
Abstract
A new class of potent and selective ligands for the human EPI prostanoid re ceptor is described. SAR studies reported herein allowed the identification of several potent dibenzazocinones bearing an acylsulfonamide side chain. The binding affinity of these compounds on all eight human prostanoid recep tors is reported. (C) 1999 Published by Elsevier Science Ltd. All rights re served.