Leishmanicidal activity of combretastin analogues and heteroanalogues

Authors
del Rey, B Ramos, AC Caballero, E Inchaustti, A Yaluff, G Medarde, M de Arias, AR San Feliciano, A
Citation
B. Del Rey et al., Leishmanicidal activity of combretastin analogues and heteroanalogues, BIOORG MED, 9(18), 1999, pp. 2711-2714
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
18
Year of publication
1999
Pages
2711 - 2714
Database
ISI
SICI code
0960-894X(19990920)9:18<2711:LAOCAA>2.0.ZU;2-5
Abstract
We have investigated the in vitro leishmanicidal activity of representative members from series II-V of combretastatin analogues and heteroanalogues. Most of them exhibited different degrees of activity against various strain s of Leishmania spp. The diaryl(heteroaryl)ethane system or the more comple x fused heterocyclic stilbenoids, constitute useful skeletal bases to suppo rt some kind of antiparasitic activity. Particularly, the incorporation of 2-furyl substituents led to potent antileishmanial compounds, which have be en selected for in vivo testing on murine models. (C) 1999 Elsevier Science Ltd. All rights reserved.