Chromosome rearrangement at 17q25 and Xp11.2 in alveolar soft-part sarcoma- A case report and review of the literature

BACKGROUND. Despite the characteristic histopathologic appearance of alveol ar soft-part sarcoma (ASPS), its histogenesis remains unclear, and cytogene tic analysis of ASPS is limited to eight cases so far because of the extrem e rarity of this disease. METHODS. The authors document a cytogenetic study of a primary case of ASPS in which a modem spectral karpotyping technique was used. RESULTS. A standard cytogenetic analysis of the primary tumor cells with G- banding revealed 46,XY add(17)(q25) in 23 of 25 metaphases analyzed. This s tructural rearrangement of chromosome 17, involving band q25, was also pres ent in 5 of 8 ASPS cases in the literature. Moreover, with the spectral kar yotyping technique, the additional part of the long arm of chromosome 17 in the current case was found to originate from chromosome X, resulting in a final tumor karyotype of 46, XY, add(17)(q25).ish der(17)t(X;17) (p11.2;q25 )(wcpX+). CONCLUSIONS. This case report documents a clonal chromosome abnormality of der(17)t(X;17)(p11.2;q25) in ASPS. The results of the current study indicat e that further molecular analyses focused on 17q25 and Xp11.2 are of intere st and could help to elucidate the pathogenesis of ASPS. Cancer 1999;86:124 6-50, (C) 1999 American Cancer Society.