Solvent-dependent conformational behaviour of lipochitoligosaccharides related to Nod factors

Authors
Gonzalez, L Bernabe, M Espinosa, JF Tejero-Mateo, P Gil-Serrano, A Mantegazza, N Imberty, A Driguez, H Jimenez-Barbero, J
Citation
L. Gonzalez et al., Solvent-dependent conformational behaviour of lipochitoligosaccharides related to Nod factors, CARBOHY RES, 318(1-4), 1999, pp. 10-19
Citations number
45
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE RESEARCH
ISSN journal
00086215 → ACNP
Volume
318
Issue
1-4
Year of publication
1999
Pages
10 - 19
Database
ISI
SICI code
0008-6215(19990531)318:1-4<10:SCBOLR>2.0.ZU;2-V
Abstract
The solution conformation of two lipooligosaccharides related to Nod factor s or lipochitoligosaccharides have been analysed by 1D and 2D H-1 and (13) NMR spectroscopy, molecular mechanics and dynamics calculations. The obtain ed data indicate that the glycosidic torsion angles have restricted fluctua tions, but may adopt a variety of shapes. Remarkably, the relative orientat ion of the fatty acid chain towards the oligosaccharide backbone is solvent dependent. In water solution, the acyl residue and the oligosaccharide ado pt a quasi-parallel orientation for a significant amount of time. (C) 1999 Elsevier Science Ltd. All rights reserved.