Isolation and structural determination of new sphingolipids and pharmacological activity of africanene and other metabolites from Sinularia leptoclados
Srg. Bala et al., Isolation and structural determination of new sphingolipids and pharmacological activity of africanene and other metabolites from Sinularia leptoclados, CHEM PHARM, 47(9), 1999, pp. 1214-1220
Two new sphingolipids, (2S,3S,4R)-1,3,4-trihydroxy-2-[((R)-2'-hydroxytetrad
ecanoyl) amino] tricosane (4) and (2S,3S,4R)-1,3,4-triacetoxy-2-[((R)-2'-ac
etoxyoctadecanoyl) amino]octadecane (5) along with africanene (1, reasonabl
y good yield), 23-demethylgargosterol (2) and batylalcohol (3) have been is
olated from the soft coral Sinularia leptoclados. Preliminary studies for p
harmacological activity (blind screening and toxicity studies) of africanen
e were conducted. Africanene exhibited in vitro and in vivo cytotoxicity, d
ose dependent hypotensive activity as well as antiinflammatory activity The
pharmacological and toxicity studies on africanene are being reported for
the first time and findings strongly encourage further investigation, Compo
unds 1, 4 and 5 were studied for the antibacterial, antifungal and antivira
l activity while compounds 4 and 5 were also studied for the short term in
vitro cytotoxic activity.