A new and efficient synthesis of 2-methyl-3-nitro-1,2-dihydropyridines by heterocyclic annulation reactions of sec-nitrodienamines with acetaldehyde

Authors
Koike, T Shinohara, Y Tanabe, M Takeuchi, N Tobinaga, S
Citation
T. Koike et al., A new and efficient synthesis of 2-methyl-3-nitro-1,2-dihydropyridines by heterocyclic annulation reactions of sec-nitrodienamines with acetaldehyde, CHEM PHARM, 47(9), 1999, pp. 1246-1248
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
9
Year of publication
1999
Pages
1246 - 1248
Database
ISI
SICI code
0009-2363(199909)47:9<1246:ANAESO>2.0.ZU;2-Z
Abstract
The sec-nitrodienamines 3 were prepared by reaction of the tert-nitrodienam ine 1 with primary amines. The reaction of 3 with acetaldehyde afforded 2-m ethyl-3-nitro-1,2-dihydropyridines 5, providing a new and efficient heteroc yclic annulation reaction.