Condensed-purines syntheses of tetrahydro-1,4-diazepino[1,2,3-gh]purin-2-one and hexahydro-1,4-diazocino[1,2,3-gh]purin-2-one

Authors
Suzuki, H Sawanishi, H Yamamoto, K Miyamoto, K
Citation
H. Suzuki et al., Condensed-purines syntheses of tetrahydro-1,4-diazepino[1,2,3-gh]purin-2-one and hexahydro-1,4-diazocino[1,2,3-gh]purin-2-one, CHEM PHARM, 47(9), 1999, pp. 1322-1325
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
9
Year of publication
1999
Pages
1322 - 1325
Database
ISI
SICI code
0009-2363(199909)47:9<1322:CSOT>2.0.ZU;2-V
Abstract
1,4-Pyrimido- (2a), 1,4-diazepino- (2b), and 1,4-diazocino[1,2,3-gh]purine (2c) were designed as selective cAMP-phosphodiesterase 4 (PDE 4) inhibitors . The desired condensed-purines (2b,c) were synthesized by reaction of 7-am inoalkyl-3-propylpurine-2,4-diones (6b,c) with hexamethyldisilazane by intr amolecular cyclization via silylation-amination.