Thermal hetero [3+2] cycloaddition of dipolar trimethylenemethane to N-sulfonyl and N-acyl imines. Synthesis of gamma-amino acid derivatives

Authors
Yamago, S Yanagawa, M Nakamura, E
Citation
S. Yamago et al., Thermal hetero [3+2] cycloaddition of dipolar trimethylenemethane to N-sulfonyl and N-acyl imines. Synthesis of gamma-amino acid derivatives, CHEM LETT, (9), 1999, pp. 879-880
Citations number
13
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
9
Year of publication
1999
Pages
879 - 880
Database
ISI
SICI code
0366-7022(199909):9<879:TH[COD>2.0.ZU;2-J
Abstract
Thermal hetero [3 + 2] cycloaddition reaction of a dipolar trimethylenemeth ane 2 with an N-acyl or N-tosyl imine gives an alpha-methylene-gamma-pyrrol idone acetal 4 in high yield, which upon hydrolysis affords a gamma-amino a cid derivative.