A new type of orally active insulin-mimetic vanadyl complex: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S2O2) coordination mode

Authors
Sakurai, H Sano, H Takino, T Yasui, H
Citation
H. Sakurai et al., A new type of orally active insulin-mimetic vanadyl complex: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S2O2) coordination mode, CHEM LETT, (9), 1999, pp. 913-914
Citations number
22
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
9
Year of publication
1999
Pages
913 - 914
Database
ISI
SICI code
0366-7022(199909):9<913:ANTOOA>2.0.ZU;2-O
Abstract
A new purple vanadyl complex, bis(1-oxy-2-pyridinethiolato) oxovanadium(IV) , VO(OPT), with VO(S2O2) coordination mode, was prepared by mixing 2-mercap topyridine-N-oxide or 1-hydroxy-2-pyridinethione and VOSO4,, and characteri zed by UV, IR and EPR spectra, magnetic susceptibility and partition coeffi cient. Based on the higher in vitro insulin-mimetic activity of VO(OPT) (IC 50=0.19 mM) than that of VOSO4, (IC50=0.9 mM), the complex was found to be a potent agent for treating insulin-dependent diabetes mellitus in rats whe n given by daily intravenous injection or oral administration.