Functional regulation of myoglobin by iron corrphycene

Authors
Neya, S Funasaki, N Hori, H Imai, K Nagatomo, S Iwase, T Yonetani, T
Citation
S. Neya et al., Functional regulation of myoglobin by iron corrphycene, CHEM LETT, (9), 1999, pp. 989-990
Citations number
12
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
9
Year of publication
1999
Pages
989 - 990
Database
ISI
SICI code
0366-7022(199909):9<989:FROMBI>2.0.ZU;2-H
Abstract
Iron corrphycene, a novel isomeric heme, was incorporated into myoglobin to examine the influence of heme deformation on the function. The reconstitut ed protein, although functionally active, exhibits extremely lower affiniti es for O-2 and CO as compared with the native protein. The functional anoma ly was explained in terms of modified iron reactivity in the trapezoidal co ordination core.