Effects of PKCa antisense RNA on human breast cancer cell proliferation and expression of cyclinD1 and CDK4

Authors
Sang, JL Wang, YC
Citation
Jl. Sang et Yc. Wang, Effects of PKCa antisense RNA on human breast cancer cell proliferation and expression of cyclinD1 and CDK4, CHIN SCI B, 44(12), 1999, pp. 1110-1114
Citations number
12
Categorie Soggetti
Multidisciplinary
Journal title
CHINESE SCIENCE BULLETIN
ISSN journal
10016538 → ACNP
Volume
44
Issue
12
Year of publication
1999
Pages
1110 - 1114
Database
ISI
SICI code
1001-6538(199906)44:12<1110:EOPARO>2.0.ZU;2-0
Abstract
The role of PKC alpha in human breast cancer cell proliferation and express ion of cyclinD1 and CDK4 has been investigated using inhibition of PKC alph a expression by its antisense RNA. When PKC alpha expression was inhibited the rate of cell proliferation decreased apparently and the levels of cycli nD1 and CDK4 mRNA were lower than the control. The results showed that PKC alpha, a key member of signal transduction system, played an important role in human breast cancer cell proliferation and had a close relationship wit h expression of cyclinD1 and CDK4 which control start of cell cycle.