Relevance of Fc gamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients

Authors
Sugita, N Yamamoto, K Kobayashi, T Van der Pol, WL Horigome, T Yoshie, H Van de Winkel, JGJ Hara, K
Citation
N. Sugita et al., Relevance of Fc gamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients, CLIN EXP IM, 117(2), 1999, pp. 350-354
Citations number
37
Categorie Soggetti
Immunology
Journal title
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
ISSN journal
00099104 → ACNP
Volume
117
Issue
2
Year of publication
1999
Pages
350 - 354
Database
ISI
SICI code
0009-9104(199908)117:2<350:ROFGRP>2.0.ZU;2-G
Abstract
The immunoglobulin receptor Fc gamma RIIIa (CD16) is distributed on natural killer (NK) cells, macrophages, and gamma delta T cells, and is polymorphi c. Fc gamma RIIIa-158V has a higher affinity for both monomeric and immune complexed IgG1, IgG3, and IgG4 than IIIa-158F. We determined Fc gamma RIIIa -158V/F genotypes of Japanese patients with adult periodontitis. A signific ant over-representation of Fc gamma RIIIa-158F was found in patients with r ecurrence, compared with patients without recurrence, making Fc gamma RIIIA a candidate gene for recurrence risk of adult periodontitis.