1998 GCMAS Best Paper Award - Double-blind study of botulinum A toxin injections into the gastrocnemius muscle in patients with cerebral palsy

The purpose of this study was to quantify the gait of subjects receiving tw o injections of either botulinum A toxin or saline vehicle into the gastroc nemius muscle(s). The study group consisted of cerebral palsy patients who walked with an equinus gait pattern. This study was a randomized, double-bl inded, parallel clinical trial of 20 subjects. All were studied by gait ana lysis before and after the injections. There were no adverse effects. Peak ankle dorsiflexion in stance and swing significantly improved in subjects w ho received the drug and not in controls. Results of this double blind stud y give support to the short term efficacy of botulinum toxin A to improve g ait in selected patients with cerebral palsy. (C) 1999 Elsevier Science B.V . All rights reserved.