Molecular anthropology has brought new possibilities into the study of anci
ent human populations. Amplification of chromosomal short tandem repeat (ST
R) loci and mitochondrial DNA (mtDNA) has been successfully employed in ana
lyses of ancient bone material. Although several studies have reported on c
ontinental Amerindian populations, none have addressed the ancient populati
ons inhabiting the Caribbean islands. We used STR and mtDNA analyses to stu
dy the skeletal remains of a Cuban Ciboney female adult holding an infant.
Results showed that for the STR analyzed the skeletal remains shared common
alleles, suggesting a relationship. Mitochondrial DNA analysis showed sequ
ence identity, thus corroborating a possible mother-child relationship. The
mtDNA sequence grouped these remains into haplogroup A, commonly found in
Amerindian populations. Based on these results, we speculated on a South Am
erican origin of pre-Columbian Antilles populations.