Issues in implementing prenatal screening for cystic fibrosis: Results of a working conference

Purpose: To summarize a conference convened to examine how cystic fibrosis screening might appropriately be introduced into routine prenatal practice. Methods: Participants included experts from various relevant disciplines. Systematic reviews and data from individual trials were presented; issues w ere identified and discussed. Results: Judged by published criteria, prenat al cystic fibrosis screening is suitable for introduction. Screening can be performed cost-effectively by identifying racial/ethnic groups at sufficie nt risk and then using either of two models for delivering laboratory servi ces. Validated educational materials exist. Ethical issues are not unique. Conclusions: Once adequate facilities for patient and provider education, t esting, counseling, quality control, and monitoring are in place, individua l programs can begin prenatal screening for cystic fibrosis.