Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant condition clinically characterized by behavioral, cognitive, and motor disturbances. Until now, at least 13 different FTDP-17 families that show linkage to chromosome 17q21 have been described. To cha racterize the FTDP-17 candidate region, flanked by the markers D17S1789 and D17S1804, we constructed a physical map in P1 and PAC clones. A detailed t ranscript map was generated by positioning known genes and EST clusters to the physical map. In total, we investigated 150 STSs mapped to this region. In addition, novel transcripts were isolated by exon-trapping. We were abl e to localize 19 known genes and a number of ESTs to this chromosomal regio n, Furthermore, seven novel genes were identified for which we isolated the full-length sequence. (C) 1999 Academic Press.