Cloning and mapping of members of the MYM family

Tandem repeats of a novel, putative, zinc-binding motif (MYM) have been des cribed within the products of two, highly homologous genes: ZNF198/RAMP/FIM and ZNF261/DXS6673E. ZNF198, mapping to 13q11-q12, was recently shown to f use to the fibroblast growth factor receptor 1 gene in the t(8;13)(p11;q11- q12) rearrangement associated with a stem cell leukemia/lymphoma syndrome. ZNF261 at Xq13.1 is disrupted by a t(X;13)(q13.1;q32) rearrangement in a me ntally retarded patient and is a candidate gene for nonspecific X-linked me ntal retardation. Here we have cloned another member of this family, design ated ZNF258, and mapped it to chromosome band 14q12, In addition, ZNF262/KI AA0425 was identified as a further member of the family and mapped to 1p32- p34. The predicted protein products of ZNF258 and ZNP262 maintain the repea ts of the MYM motif. Isolation of these new members will facilitate the fun ctional characterization of the MYM family and motif, (C) 1999 Academic Pre ss.