THE EFFECT OF CYCLOSPORINE-A ON HG2-POISONING MITOCHONDRIA - IN-VIVO AND IN-VITRO STUDIES()

Authors
CHAVEZ R CORONA N GARCIA C CHAVEZ E
Citation
R. Chavez et al., THE EFFECT OF CYCLOSPORINE-A ON HG2-POISONING MITOCHONDRIA - IN-VIVO AND IN-VITRO STUDIES(), Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 107(3), 1994, pp. 429-434
Citations number
29
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology → ACNP
ISSN journal
13678280
Volume
107
Issue
3
Year of publication
1994
Pages
429 - 434
Database
ISI
SICI code
1367-8280(1994)107:3<429:TEOCOH>2.0.ZU;2-X
Abstract
The protective effect of cyclosporin A on the damage induced by Hg2+ i n kidney mitochondria was studied. Cyclosporin, added in vitro at a co ncentration of 0.5 muM, reversed the deleterious effects of Hg2+ on tr ansmembrane potential and Ca2+ accumulation. However, when injected in rats, together with Hg2+, cyclosporin failed to protect against Hg2poisoning. Due to the low activity of cyclophilin found in kidney mitc hondria, it is proposed that the protection of cyclosporin in vitro mu st be exerted through an independent mechanism different from its bind ing to cyclophilin.