R. Chavez et al., THE EFFECT OF CYCLOSPORINE-A ON HG2-POISONING MITOCHONDRIA - IN-VIVO AND IN-VITRO STUDIES(), Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 107(3), 1994, pp. 429-434
The protective effect of cyclosporin A on the damage induced by Hg2+ i
n kidney mitochondria was studied. Cyclosporin, added in vitro at a co
ncentration of 0.5 muM, reversed the deleterious effects of Hg2+ on tr
ansmembrane potential and Ca2+ accumulation. However, when injected in
rats, together with Hg2+, cyclosporin failed to protect against Hg2poisoning. Due to the low activity of cyclophilin found in kidney mitc
hondria, it is proposed that the protection of cyclosporin in vitro mu
st be exerted through an independent mechanism different from its bind
ing to cyclophilin.