Trisomy 21 associated with ovarian dysgerminoma

A 13-year-old G(0)P(0) white female with trisomy 21 presented with a comple x pelvic mass. She underwent resection of the mass and complete staging for what was found to be a stage IIIC completely resected dysgerminoma. She wa s treated with three cycles of bleomycin, etoposide, and cisplatin chemothe rapy and remains free of disease 1 year later. This association is presente d as a rare case that may illustrate the relative increase in germ cell neo plasms in female patients with Down's syndrome. While the association of se minoma with Down's syndrome has been documented in a number of cases in mal es, the female counterpart of this tumor, dysgerminoma, in trisomy 21 has b een reported quite infrequently. The potential for germ cell tumors in both male and female trisomy 21 is therefore illustrated. (C) 1999 Academic Pre ss.