Nuclear probes in life sciences

The nuclear quadrupole interaction at metal sites in macromolecules monitor ed by time differential perturbed angular correlation provides information on the local environment of metal ions residing at these sites. This inform ation is obtained in the ultra-trace regime and is, therefore, extremely va luable for research on reaction pathways of enzymatic heavy metal detoxific ation, for the development of radiopharmaceuticals, for investigations into protein architectures on surfaces, and for environmental research.