SYNTHESIS OF A RADIOLABELED RETINOID-X-RECEPTOR (RXR) SPECIFIC LIGAND

Authors
HELD P HECK MP IYER J GRONEMEYER H LEBEAU L MIOSKOWSKI C
Citation
P. Held et al., SYNTHESIS OF A RADIOLABELED RETINOID-X-RECEPTOR (RXR) SPECIFIC LIGAND, Journal of labelled compounds & radiopharmaceuticals, 39(6), 1997, pp. 501-507
Citations number
11
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
6
Year of publication
1997
Pages
501 - 507
Database
ISI
SICI code
0362-4803(1997)39:6<501:SOARR(>2.0.ZU;2-E
Abstract
Synthesis of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen- 2-yl)- [1,3]dioxolan-2-yl]-benzoic acid or SR11237, a specific ligand of Reti noid X Receptors, is described in a H-3-labelled version. The labelled retinoid was prepared in 5 steps and tritium was introduced through a final reduction of an aromatic dihalide moiety with H-3(2).