Diazepam increases calcium sensitivity of the skinned cardiac muscle fiberin guinea pig

Authors
Hara, Y Chugun, A Futamura, K Nishino, T Kondo, H
Citation
Y. Hara et al., Diazepam increases calcium sensitivity of the skinned cardiac muscle fiberin guinea pig, JPN J PHARM, 81(1), 1999, pp. 122-124
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
00215198 → ACNP
Volume
81
Issue
1
Year of publication
1999
Pages
122 - 124
Database
ISI
SICI code
0021-5198(199909)81:1<122:DICSOT>2.0.ZU;2-G
Abstract
Influences of diazepam, a benzodiazepine derivative, on the contractile res ponse to calcium in skinned trabecular fibers of guinea pig heart were exam ined. Diazepam (100 mu M) enhanced the contractile response of the skinned fiber to calcium and shifted the concentration-response curve to the left. The pCa(50) values were 6.07+/-0.03 and 6.28+/-0.03 (P < 0.05) in the absen ce and presence of diazepam, respectively. This result suggests that diazep am increases calcium sensitivity of contractile proteins in heart muscles.