Human immune responses to the UK human anthrax vaccine

The IgG anti-protective antigen subclass antibody response of individuals w ho had been infected with anthrax was compared with that of healthy individ uals immunized with the UK licensed anthrax vaccine. The predominant subcla ss in both groups was IgG1. In addition, IgG3 was seen in convalescent seru m while vaccinees produced IgG2, IgG3 and IgG-C subclass. The significance of these results is discussed. Further work is required to determine the ro le of antibodies in mediating protective immunity in man.