Human herpesvirus 6 is latent in peripheral blood of patients with relapsing-remitting multiple sclerosis

Citation
A. Rotola et al., Human herpesvirus 6 is latent in peripheral blood of patients with relapsing-remitting multiple sclerosis, J NE NE PSY, 67(4), 1999, pp. 529-531
Citations number
21
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
ISSN journal
00223050 → ACNP
Volume
67
Issue
4
Year of publication
1999
Pages
529 - 531
Database
ISI
SICI code
0022-3050(199910)67:4<529:HH6ILI>2.0.ZU;2-C
Abstract
Studies of the association between HHV-6 and multiple sclerosis are hindere d by the difficulty in discriminating between latent and active infection. A follow up study was undertaken of patients with multiple sclerosis, searc hing peripheral blood mononuclear cells for molecular markers associated wi th HHV-6 latency and lytic replication. The results show that HHV-6 is late nt and did not support systemic infection in patients with multiple scleros is. Likewise, patients with multiple sclerosis did not show any evidence of active infection with other human herpesviruses HHV-7 and HHV-8.