Total synthesis of squamotacin

The first total synthesis of (+)-squamotacin, 1, which has shown cytotoxic selectivity for the human prostate tumor cell line, was; achieved in 27 ste ps and 0.83% yield starting with (+)-muricatacin, 4. All asymmetric centers in the bistetrahydrofuran fragment of the molecules were produced by the S harpless asymmetric dihydroxylation (AD) and the asymmetric epoxidation (AE ) reactions.