Can growth hormone treatment in boys without growth hormone deficiency impair testicular function?

Four young male subjects (age range, 17 4/12 to 25 5/12 years), previously treated with human growth hormone for non-growth hormone-dependent short st ature, showed reduced testicular volume and hypergonadotropic hypogonadism. They also showed impaired spermatogenesis and altered testicular texture a s determined by ultrasonography. No clinical or laboratory finding showed d isease associated with testicular dysfunction. An unfavorable gonadal outco me could occur in boys without growth hormone deficiency treated with human growth hormone.