Masculinizing granulosa cell tumor of the ovary in a postmenopausal woman - A case report

BACKGROUND: A total of 32 cases of virilizing granulosa cell tumors of the ovary have been reported. The current case has some unique not previously r eported. CASE: A 78-year-old woman presented with symptoms and signs of masculinizat ion. A large, painless abdominal mass was discovered. Exploration revealed the mass to be originating in the left ovary, and surgical resection result ed in prompt reversal of the clinical and biochemical hyperandrogenic manif estations. Morphologic studies demonstrated a homogeneous granulosa cell tu mor. CONCLUSION: This is the oldest patient on record with a masculinizing granu losa cell tumor and also the only masculinizing tumor presenting with advan ced, stage III disease. Such tumors, although rare, should be considered in the differential diagnosis in postmenopausal women presenting with masculi nizing symptoms.