Ml. Hicks et Sp. Bacon, Effects of aspirin on psychophysical, measures of frequency selectivity, two-tone suppression, and growth of masking, J ACOUST SO, 106(3), 1999, pp. 1436-1451
Three psychophysical measures of nonlinearity were evaluated before and dur
ing a course of aspirin ingestion to investigate the role of outer hair cel
ls (OHCs) in these measures, as aspirin is thought to alter the functioning
of OHCs. Six normal-hearing individuals received a moderate dose (3.9 g/da
y) of aspirin for four days, producing essentially flat, temporary hearing
losses that ranged from 5-20 dB. The losses were about 2 dB greater for a 3
00-ms signal than for a 15-ms signal, indicating reduced temporal integrati
on with aspirin. On the final three days of aspirin use, three experiments
were completed; each was designed to measure one aspect of nonlinear behavi
or: (1) the effects of level on frequency selectivity in simultaneous maski
ng using notched-noise maskers, (2) two-tone suppression using forward mask
ers at the signal frequency (f(s)) and suppressor tones above f(s), and (3)
growth-of-masking functions in forward masking using a masking tone below
f(s). Signal frequencies of 750 and 3000 Hz were used to evaluate the effec
ts of aspirin at relatively low- and high-frequency regions of the cochlea.
In experiment I, aspirin broadened the auditory filters and reduced the ef
fect of level on frequency selectivity. In experiment 2, aspirin reduced or
eliminated two-tone suppression. And, in experiment 3, aspirin reduced the
slopes of the growth-of-masking functions. Thus, the aspirin was effective
in reducing nonlinearity in all three experiments, suggesting that these m
easures reflect the same (or a similar) active, nonlinear mechanism, namely
the compressive nonlinearity provided by the OHCs. In all experiments, asp
irin tended to have larger detrimental effects on the nonlinear measures at
3000 Hz than at 750 Hz, which can be explained in terms of greater involve
ment of nonlinear processing at higher frequencies. Finally, these effects
of aspirin were found to be similar to those observed in preliminary measur
ements in two subjects with mild, permanent hearing loss. (C) 1999 Acoustic
al Society of America. [S0001-4966(99)04509-9].