Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: Considerations on its relevance to the pathogenesis ofhuman idiopathic membranous glomerulonephritis

In the course of studies on the humoral consequences of swine to primate xe notransplantation, the investigators induced formation of glomerular subepi thelial immune deposits and tubular lesions in pigs injected with heterolog ous antibody to angiotensin-converting enzyme. This study describes the mor phology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerul onephritis, and proposes future directions for investigations.