The problem of quantitative interpretation of high-resolution electron micr
oscopy is studied in the framework of parameter estimation. Ideally, quanti
tative interpretation means that unknown structural parameters of an object
such as atom types and coordinates are determined from fitting with the ex
perimental dataset. However, in the imaging process, the influence of these
parameters is completely scrambled over a large area of the image. As a co
nsequence, the fitting becomes a search process in the higher dimensional s
pace of all coupled parameters. The real importance of holographic methods
such as off-axis holography and focus variation is that they restore (deblu
r) to some extent the imaging process so as to unscramble the influence of
the different model parameters. Ln this way the dimension of the search spa
ce becomes manageable. In this framework the concept of resolution in the s
ense of Rayleigh is not valid anymore, but it has to be replaced by the not
ice of parameter precision. In case two atoms are very close, the parameter
space may become degenerate so that the atoms cannot be discriminated. The
probability of this degeneracy is a function of the distance between the a
toms and the dose of the imaging particles. (C) Elsevier Science Inc., 1999
. All rights reserved.