Cytokines, nitric oxide, heat shock proteins and virulence in Toxoplasma

Authors
Miller, CMD Smith, NC Johnson, AM
Citation
Cmd. Miller et al., Cytokines, nitric oxide, heat shock proteins and virulence in Toxoplasma, PARASIT TOD, 15(10), 1999, pp. 418-422
Citations number
46
Categorie Soggetti
Microbiology
Journal title
PARASITOLOGY TODAY
ISSN journal
01694758 → ACNP
Volume
15
Issue
10
Year of publication
1999
Pages
418 - 422
Database
ISI
SICI code
0169-4758(199910)15:10<418:CNOHSP>2.0.ZU;2-9
Abstract
Elucidating the factors that play important roles in the expression of viru lence by parasites is crucial to understanding disease pathogenesis and to developing control strategies rationally. Here, Kate Miller, Nick Smith and Alan Johnson, using Toxoplasma gondii as a model, argue that the interacti ons between the immune system and 70 kDa heat shock proteins of apicomplexa n parasites profoundly influence parasite virulence.