Synthesis of some new heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety as anti-HIV and anti-cancer drugs, part II

Some new heterobicyclic nitrogen systems 5-18 and/or thioethers 20, 22 bear ing the 1,2,4-triazine moiety have been synthesized via condensation of 3-f ormylamino-1,2,4-triazine 3 with nitrogen compounds followed by heterocycli zation with oxygen I reagents. Thioether analogs 20, 22 have been obtained from fusion of compound 19 with 4-chlorothiophenol. The structure of the pr oducts have been established by elemental analysis and spectral data. The a nti-HIV and anticancer activities of some products have also been investiga ted where compounds 20a, c and 22b exhibited a moderate activity. The bioci dal-structures activity correlation was also studied.