We studied the stability of linear vortex filaments in 3-dimensional (3D) e
xcitable media, using both analytical and numerical methods. We found an in
trinsic 3D instability of vortex filaments that is diffusion induced and is
due to the slower diffusion of the inhibitor. This instability can result
either in a single helical filament or in chaotic scroll breakup, depending
on the specific kinetic model. When the 2-dimensional dynamics were in the
chaotic regime, filament instability occurred via on-off intermittency, a
failure of chaos synchronization in the third dimension.