Reactions of uracils, 24. Multiple anellation to uracils and their analogsan approach to nevirapine-type tricycles

Authors
Wamhoff, H Sattler, C Sohar, P Rohonczy, J
Citation
H. Wamhoff et al., Reactions of uracils, 24. Multiple anellation to uracils and their analogsan approach to nevirapine-type tricycles, SYN COMMUN, 29(22), 1999, pp. 3919-3937
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
29
Issue
22
Year of publication
1999
Pages
3919 - 3937
Database
ISI
SICI code
0039-7911(1999)29:22<3919:ROU2MA>2.0.ZU;2-S
Abstract
Starting with 6-amino-1,3-dimethyluracil 1 a structural analog of the NNRTI Nevirapine 16 is synthesized in a sequence of two ring anellations and a B eckmann rearrangement. The anellation behavior of 3 is studied in general l eading to the anellated systems 5, 7a-c, 12,a-c.