An efficient chemoenzymatic access to chiral 3,7-diazabicyclo[3.3.1]nonanederivatives

Authors
Danieli, B Lesma, G Passarella, D Silvani, A Viviani, N
Citation
B. Danieli et al., An efficient chemoenzymatic access to chiral 3,7-diazabicyclo[3.3.1]nonanederivatives, TETRAHEDRON, 55(40), 1999, pp. 11871-11878
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
40
Year of publication
1999
Pages
11871 - 11878
Database
ISI
SICI code
0040-4020(19991001)55:40<11871:AECATC>2.0.ZU;2-T
Abstract
Enantiopure 3,7-diazabicyclo[3.3.1]nonane derivatives 4 and 5, potential pr ecursors of quinolizidine alkaloids, were synthesised in high yields, start ing from the biocatalytic asymmetrization of sigma-symmetric 3,5-disubstitu ted piperidines. Their application to the total synthesis of the new pharma cologically active compounds 3 are also described. (C) 1999 Elsevier Scienc e Ltd. All rights reserved.