Mv. Zaragoza et al., EARLY COMPLETE HYDATIDIFORM MOLES CONTAIN INNER CELL MASS DERIVATIVES, American journal of medical genetics, 70(3), 1997, pp. 273-277
In four cases of early complete hydatidiform moles, confirmed to be an
drogenetic in origin by DNA studies, we have identified non-chorionic
inner cell mass derived structures which are not commonly observed in
specimens of later gestational age, These structures include nucleated
red blood cells, endothelial cells, stromal macrophages, amnion and y
olk sac, The latter four structures were confirmed by specific immunoc
ytochemical stains. Recognition that such structures can accompany com
plete hydatidiform moles has both theoretical and practical significan
ce. From a theoretical perspective, it demonstrates that the maternal
genome is not required for the initiation of amniogenesis, development
of the yolk sac, vasculogenesis, or hematopoiesis, From a practical p
erspective it emphasizes that complete hydatidiform moles, with their
markedly increased risk of subsequent choriocarcinoma, cannot be exclu
ded based on the finding of ''fetal structures.'' (C) 1997 Wiley-Liss,
Inc.