E. Sakamoto et al., Treatment strategy for mucin-producing intrahepatic choiangiocarcinoma: Value of percutaneous transhepatic biliary drainage and cholangioscopy, WORLD J SUR, 23(10), 1999, pp. 1038-1044
Intrahepatic cholangiocarcinomas that secrete macroscopically excessive muc
in into the biliary system are rare, and few of the previously reported cas
es have achieved a curative resection. We defined these tumors as "mucin-pr
oducing intrahepatic cholangiocarcinomas'' and clarify the optimal preopera
tive and surgical management for them. Eleven patients with mucin-producing
intrahepatic cholangiocarcinomas underwent surgical resection in our depar
tment. The clinical, radiologic, surgical, and pathologic findings were stu
died. The clinical presentation of the 11 patients included repeated abdomi
nal pain, jaundice, and fever. Conventional cholangiographies, such as perc
utaneous transhepatic cholangiography or endoscopic retrograde cholangiogra
phy, could not offer precise information about tumor location and extension
because of abundant mucin in the biliary system. Using percutaneous transh
epatic biliary drainage (PTBD) and percutaneous transhepatic cholangioscopy
(PTCS), we were able to drain the mucin and determine precisely the cancer
extension into intrahepatic segmental bile ducts. Based on these findings,
various types of liver resection,vith or without extrahepatic bile duct re
section were planned, and 10 patients obtained curative resection. The cumu
lative 5-year survival rate after curative resection was 78%. In patients w
ith mucin-producing intrahepatic cholangiocarcinoma, PTBD and PTCS are impo
rtant for evaluating the cancer extension. Rational surgery based on accura
te preoperative diagnosis improved the prognosis of patients with this dise
ase.