Familial coarctation of the aorta in three generations

Four members in three generations of a family were affected by a coarctatio n of the aorta (CoA) which was mild or severe, either isolated or in associ ation with other cardiac defects, This family suggests that a rare form of CoA could be the result of an autosomal dominant mutation with incomplete p enetrance and variable expressivity rather than polygenic inheritance.