Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease

Authors
Ojaimi, J Masters, CL McLean, C Opeskin, K McKelvie, P Byrne, E
Citation
J. Ojaimi et al., Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease, ANN NEUROL, 46(4), 1999, pp. 656-660
Citations number
21
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134 → ACNP
Volume
46
Issue
4
Year of publication
1999
Pages
656 - 660
Database
ISI
SICI code
0364-5134(199910)46:4<656:IDOCCO>2.0.ZU;2-R
Abstract
This study aims to investigate the cellular distribution of human cytochrom e c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in t he cerebellar Purkinje cells were reduced in age-matched controls relative to young controls and in the Alzheimer's disease group relative to both age -matched and young controls. Results suggest that these age-associated chan ges are more marked in Alzheimer's disease.